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. 2021 Apr 20;53(4):548–559. doi: 10.1038/s12276-021-00611-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — miR-30b-5p and miR-34a downregulate autophagy-related gene expression by directly inhibiting TFs, such as transcription factor EB (TFEB), Hnf4α, peroxisome proliferator-activated receptor alpha (PPARα), and NAD-dependent protein deacetylase sirtuin 1 (SIRT1). Liver X receptor-α (LXRα) transcriptionally activates miR-34a and let7a, which directly target the 3’UTR of Atg4B and Rab8b. miR-214-3p and HNF4α reciprocally regulate Ulk1 expression.