Table 2.
Metabolic phenotypes of CRH and TRH neuronal activity modulation.
| Target nucleus | Neuronal population (animal model) | Modulation of neuronal activity (viral construct) | Involved neural circuitry | Observed phenotype | Ref. |
|---|---|---|---|---|---|
| PVH |
CRH neuron (Crh-ires-cre mouse) |
Chemogenetic inhibition (AAV8-DIO-hM4Di-mCherry) |
N.D. | ↔ Food intake | 60 |
|
CRH neuron (Crh-ires-cre mouse) |
Neuronal ablation (AAV-DJ-CMV-DIO-eGFP-2A-TeNT) |
N.D. |
↔ Food intake ↔ Body weight |
61 | |
|
CRH neuron (Crh-ires-cre mouse) |
Chemogenetic activation (AAV-hSyn-DIO-hM3Dq-mCherry) |
N.D. | ↓ Food intake | 62 | |
|
Chemogenetic inhibition (AAV-hSyn-DIO-hM4Di-mCherry) |
N.D. | ↓ Anorexia by GLP-1 | |||
|
TRH neuron (Trh-ires-cre mouse) |
Chemogenetic activation (AAV8-DIO-hM3Dq-mCherry) |
Glutamatergic innervation of AgRP neurons within the ARH | ↑ Food intake | 14 | |
| CeA |
CRH neuron (Crh-ires-cre mouse) |
Optogenetic activation (AAV2-EF1α-DIO-ChR2-EYFP) |
N.D. | ↔ Food intake | 73 |
|
CRH neuron (Crh-ires-cre mouse) |
Chemogenetic activation (AAV2-hSyn-DIO-hM3Dq-mCherry) |
N.D. |
↔ Food intake (basal) ↓ Food intake (with stress) |
77 | |
| BNST |
CRH neuron (Crh-ires-cre mouse) |
Chemogenetic activation (AAV5-EF1α-DIO-hM3Dq-mCherry) |
N.D. |
↔ Food intake ↔ Body weight |
78 |
N.D. not determined, see text for abbreviations.