Table 3.
Metabolic effects of exogenous HPT axis hormones.
| Hormone | Application routes (animal model) | Food intake | Body weight | Energy expenditure parameters | Glucose balance | Lipid metabolism | Ref. |
|---|---|---|---|---|---|---|---|
| T3 |
s.c. injection (rat) |
↑ | ↔ |
↔ VO2 (single or short-term injections) ↑ VO2 (long-term injections) |
N.D. | N.D. | 86 |
|
i.c.v. injection (rat) |
↔ | ↓ | ↑ BAT thermogenesis | N.D. |
↔ Blood TG ↔ Blood FFA ↑ Liver TG |
91,92 | |
|
VMH injection (rat) |
↔ or ↑ | ↓ |
↑ BAT thermogenesis ↓ RER ↓ Locomotive activity |
N.D. |
↑ Blood TG ↑ Hepatic lipogenesis |
86,91,92 | |
| TRH |
s.c. injection (rat) |
↓ | ↔ | ↑ Body temperature | N.D. | N.D. | 98 |
|
i.c. injection (rat) |
↓ | N.D. | N.D. | N.D. | N.D. | 99 | |
|
i.c.v. injection (rat) |
↓ | N.D. | N.D. | ↑ Glucose | N.D. | 9,99,100 | |
|
i.c.v. injection (hamster) |
N.D. | N.D. | ↑ BAT temperature | N.D. | N.D. | 101 | |
|
PVH injection (rat) |
N.D. | N.D. | ↑ Body temperature | ↑ Glucose | N.D. | 102 | |
|
VMH injection (rat) |
↔ | N.D. | ↑ Locomotive activity | N.D. | N.D. | 104 | |
|
VMH injection (hamster) |
N.D. | N.D. | ↑ BAT temperature | N.D. | N.D. | 101 | |
|
DMH injection (hamster) |
N.D. | N.D. | ↑ BAT temperature | N.D. | N.D. | 101 | |
|
LHA injection (rat) |
↓ | N.D. | ↔ Locomotive activity | N.D. | N.D. | 104 | |
|
LHA injection (hamster) |
N.D. | N.D. | ↔ BAT temperature | N.D. | N.D. | 101 |
N.D. not determined, see text for abbreviations.