Table 1.
Genes mapped to the Sirtuin signaling pathway identified as differentially expressed in visceral adipose tissue between calves fed high or moderate energy diets during the early life period up to 21 weeks of age.
| Gene ID | Gene Name | Fold Changea | FDRb |
|---|---|---|---|
| ACLY | ATP citrate lyase | 4.067 | 5.36E−07 |
| ACSS2 | Acyl-CoA synthetase short chain family member 2 | 3.041 | 5.98E−06 |
| AKT1 | AKT serinethreonine kinase 1 | − 1.515 | 0.000398 |
| ARNTL | Aryl hydrocarbon receptor nuclear translocator like | 1.586 | 0.0172 |
| G6PD | Glucose-6-phosphate dehydrogenase | 2.684 | 1.19E−07 |
| GOT2 | Glutamic-oxaloacetic transaminase 2 | 1.634 | 0.0182 |
| HIF1A | Hypoxia inducible factor 1 subunit alpha | − 1.954 | 0.00512 |
| HIST1H4J | Histone cluster 1 H4 family member j | − 1.762 | 0.0397 |
| LDHB | Lactate dehydrogenase B | 1.767 | 0.00103 |
| LDHC | Lactate dehydrogenase C | 2.285 | 0.00283 |
| LDHD | Lactate dehydrogenase D | 1.965 | 0.000112 |
| MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha | 1.622 | 0.0313 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 2.002 | 0.000422 |
| MT-CYB | Cytochrome b | 2.14 | 0.00139 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | 1.984 | 0.000177 |
| MT-ND2 | MTND2 | 1.727 | 0.00409 |
| MT-ND3 | NADH dehydrogenase, subunit 3 (complex I) | 2.518 | 2.24E−05 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | 2.189 | 0.000069 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 1.972 | 0.00236 |
| MT-ND4L | NADH dehydrogenase, subunit 4L (complex I) | 2.364 | 0.00496 |
| MYC | MYC proto-oncogene, bHLH transcription factor | − 2.287 | 8.77E−05 |
| NDUFA1 | NADH:ubiquinone oxidoreductase subunit A1 | 1.916 | 2.31E−05 |
| NDUFA2 | NADH:ubiquinone oxidoreductase subunit A2 | 1.687 | 0.00867 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 1.666 | 0.0227 |
| NDUFA10 | NADH:ubiquinone oxidoreductase subunit A10 | 2.002 | 0.0018 |
| NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13 | 1.783 | 0.0121 |
| NDUFAB1 | NADH:ubiquinone oxidoreductase subunit AB1 | 1.692 | 0.0399 |
| NDUFB3 | NADH:ubiquinone oxidoreductase subunit B3 | 1.521 | 0.0374 |
| NDUFS2 | NADH:ubiquinone oxidoreductase core subunit S2 | 1.719 | 0.00614 |
| NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3 | 1.659 | 0.0354 |
| NDUFS6 | NADH:ubiquinone oxidoreductase subunit S6 | 1.737 | 0.0249 |
| NDUFV1 | NADH:ubiquinone oxidoreductase core subunit V1 | 2.138 | 0.00159 |
| NQO1 | NAD(P)H quinone dehydrogenase 1 | 2.409 | 7.66E−08 |
| PCK1 | Phosphoenolpyruvate carboxykinase 1 | 2.351 | 0.00332 |
| PDHA1 | Pyruvate dehydrogenase E1 alpha 1 subunit | 1.63 | 0.0214 |
| PGAM1 | Phosphoglycerate mutase 1 | 1.523 | 0.0123 |
| SDHA | Succinate dehydrogenase complex flavoprotein subunit A | 2.162 | 0.000183 |
| SDHC | Succinate dehydrogenase complex subunit C | 1.507 | 0.0155 |
| SIRT3 | Sirtuin 3 | 1.793 | 0.000281 |
| SLC25A4 | Solute carrier family 25 member 4 | 2.19 | 0.0102 |
| SOD1 | Superoxide dismutase 1 | 1.585 | 0.00044 |
| SOD2 | Superoxide dismutase 2 | 1.853 | 0.000523 |
| TIMM23 | Translocase of inner mitochondrial membrane 23 | 1.72 | 0.00399 |
| Tomm5 | Translocase of outer mitochondrial membrane 5 | 2.002 | 0.00326 |
| TUBA1B | Tubulin alpha 1b | − 1.664 | 0.0242 |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur Polypeptide 1 | 1.659 | 0.022 |
aFold change values are up- or down-regulated in high energy diet group compared to the moderate energy diet group.
bFalse Discovery Rate.