Fig. 2. Predicted metabolite secretion profiles for the 108 microbiomes.
a–f Total metabolite secretion fluxes (mmol/person/day) predicted for the microbiomes of 20 paediatric Crohn’s Disease patients with dysbiosis (IBD_dysbiotic), 63 paediatric Crohn’s Disease patients without dysbiosis (IBD_nondysbiotic), and 25 healthy control children (Healthy) for selected metabolites of interest. g Random forests analysis showing the secreted metabolites that best stratified the 20 dysbiotic and 63 dysbiotic IBD microbiomes ranked by their contributions to classification accuracy (represented by the variable MeanDecreaseAccuracy).