Table 2.
Meta-regression analysis to predict the influence of differences of age, BMI, and blood pressure between women with and without gestational diabetes mellitus on lipid profile measurements.
| Lipid | Covariate | No. of studies | Coef. | 95% CI | P | I2_res |
|---|---|---|---|---|---|---|
| TG | Age difference | 229 | 0.002 | -0.002 to 0.005 | 0.312 | 94.59% |
| Pre-BMI difference | 118 | 0.017 | -0.010 to 0.043 | 0.226 | 92.82% | |
| BMI difference | 138 | 0.058 | 0.022 to 0.094 | 0.002 | 91.52% | |
| SBP difference | 68 | 0.059 | 0.030 to 0.088 | < 0.001 | 89.97% | |
| DBP difference | 67 | 0.000 | -0.001 to 0.001 | 0.927 | 92.39% | |
| Gestational weeks at blood sampling | 117 | 0.003 | -0.008 to 0.014 | 0.545 | 91.89% | |
| TC | Age difference | 231 | 0.000 | -0.005 to 0.004 | 0.810 | 89.63% |
| Pre-BMI difference | 119 | -0.010 | -0.057 to 0.038 | 0.685 | 90.56% | |
| BMI difference | 140 | 0.051 | 0.004 to 0.098 | 0.034 | 89.38% | |
| SBP difference | 71 | 0.041 | 0.006 to 0.077 | 0.024 | 89.71% | |
| DBP difference | 71 | 0.001 | -0.001 to 0.002 | 0.486 | 91.19% | |
| Gestational weeks at blood sampling | 120 | -0.007 | -0.020 to 0.007 | 0.344 | 96.04% | |
| HDL-C | Age difference | 209 | 0.001 | -0.002 to 0.003 | 0.662 | 91.46% |
| Pre-BMI difference | 104 | 0.001 | -0.021 to 0.022 | 0.936 | 83.05% | |
| BMI difference | 134 | -0.019 | -0.044 to 0.005 | 0.114 | 92.54% | |
| SBP difference | 65 | -0.026 | -0.050 to -0.002 | 0.033 | 93.80% | |
| DBP difference | 64 | 0.000 | 0.000 to 0.000 | 0.900 | 80.20% | |
| Gestational weeks at blood sampling | 108 | -0.001 | -0.009 to 0.006 | 0.743 | 93.02% | |
| LDL-C | Age difference | 206 | 0.001 | -0.002 to 0.004 | 0.696 | 96.03% |
| Pre-BMI difference | 100 | 0.005 | -0.050 to 0.060 | 0.856 | 91.86% | |
| BMI difference | 130 | 0.030 | -0.012 to 0.072 | 0.154 | 88.77% | |
| SBP difference | 61 | 0.019 | -0.015 to 0.053 | 0.266 | 89.74% | |
| DBP difference | 61 | 0.000 | -0.001 to 0.001 | 0.951 | 92.51% | |
| Gestational weeks at blood sampling | 104 | -0.005 | -0.016 to 0.005 | 0.294 | 90.87% | |
| VLDL-C | Age difference | 16 | 0.002 | -0.107 to 0.111 | 0.970 | 90.11% |
| Pre-BMI difference | 6 | 0.103 | -0.319 to 0.526 | 0.535 | 93.50% | |
| BMI difference | 11 | 0.089 | -0.067 to 0.245 | 0.230 | 81.51% | |
| SBP difference | insufficient observations | |||||
| DBP difference | insufficient observations | |||||
| Gestational weeks at blood sampling | 7 | 0.001 | -0.077 to 0.080 | 0.970 | 79.36% |
Note: Age/Pre-BMI/BMI/SBP/DBP differences were calculated as age/BMI before pregnancy/BMI during pregnancy/Systolic blood pressure /Distal blood pressure in women with GDM deducted by those parameters in pregnant women without GDM.