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. 2021 Apr 23;12:646775. doi: 10.3389/fimmu.2021.646775

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Copyright © 2021 Li, Dou, Zhang, Zhu, Cao and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ghrelin regulates KLF4/MMP2 axis by activating SIRT1 and affects intestinal dysfunction in sepsis. (A), Western blot analysis of the expression of SIRT1, KLF4 and MMP2. (B), The expression of SIRT1, KLF4 and MMP2 determined by RT-qPCR. (C), Gastrin secretion in each group. (D), The accumulated gastric acid secretion. ^* p < 0.05 vs. CLP group. The measurement data were expressed as mean ± standard deviation. One-way ANOVA was used for the comparison among multiple groups, followed by Tukey’s post hoc tests.