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. 2021 Apr 23;12:646775. doi: 10.3389/fimmu.2021.646775

Figure 6.

Figure 6

Schematic summarizing the identified mechanism by which Ghrelin acts in sepsis-induced intestinal dysfunction. Ghrelin upregulates KLF4 expression to inhibit MMP2 level by activating SIRT1, which can alleviate the intestinal dysfunction and thereby attenuate sepsis.