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. 2021 Apr 23;8:676267. doi: 10.3389/fcvm.2021.676267

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Copyright © 2021 Ranjan, Kumari, Goswami, Li, Pal, Suleiman, Cheng, Krishnamurthy, Kishore and Verma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibrosis miRNA array along with expression profile and validation of selected miRNAs in exosomes. (A) Fibrosis-miRNA array was performed in neonatal rat fibroblast-derived exosomes after TGFβ activation. Heat map of fibrotic miRNA array data suggest an altered expression of miRNAs in TGFβ-activated FB-derived exosomes as compared to control exosome. The change in expression of selected miRNAs was further confirmed by qPCR by comparing the expression of miRNAs (B) miR-132-3p, (C) miR-200a-3p, and (D) miR-125b-5p, in activated-FB-derived exosomes. P < 0.05 vs. control exosome and PBS treatment.