Table 2. Comparison of symptom, examination, and cytologic findings of the groups before and after treatment.

	Sodium hyaluronate (n = 31)	Estradiol hemihydrate (n = 30)	Promestriene (n = 30)	P1	P3
Composite score values
Before	5.03 ± 2.82	4.77 ± 2.92	4.47 ± 3.00	0.754	0.604
After	1.93 ± 2.00	1.90 ± 1.63	1.17 ± 1.37a	0.143	0.031*
Pre-post treatment difference	3.10 ± 2.01	2.87 ± 1.81	3.30 ± 2.35	0.720	0.874
P2	< 0.001*	< 0.001*	< 0.001*
Vaginal atrophy appearance
Before	29 (93.5)	29 (96.7)	29 (96.7)	0.789	-
After	7 (22.6)	9 (30.0)	3 (10.0)	0.156	-
P2	< 0.001*	< 0.001*	< 0.001*
Vaginal pH value
Before	6 [5.5–6.0]	6 [5.5–6.0]	5.75 [5.5–6.0]	0.215	-
After	5.5 [5.0–6.0]	5 [5.0–5.5]	5 [5.0–5.5]	0.423	-
Pre-post treatment difference	0.61 ± 0.53	0.68 ± 0.51	0.52 ± 0.55	0.484	0.682
P2	< 0.001*	< 0.001*	< 0.001*
Vaginal maturation index (VMI)
Before	55 [12.5–90]	52.5 [8.7–82.1]	60 [12.5–95]	0.636	-
After	90 [25–95]	95 [60–95]	88.75 [31.8–95]	0.399	-
Pre-post treatment difference	0 [0–25]a	7 [4.38–41.25]	6.25 [0–30]	0.031*	-
P2	0.022*	< 0.001*	0.003*
Superficial cell counts by groups
Before	30 [5–80]	20 [0–73.75]	30 [5–80]	0.747	-
After	80 [10–90]	90 [28.75–90]	80 [8.75–90]	0.418	-
Pre-post treatment difference	0 [0–30]	10 [3–70]	5 [0–35]	0.064	-
P2	0.009*	< 0.001*	0.008*
Sexual activity (number/month)
Before	4 [2–4]	2 [1–4]	3.5 [2–4]	0.384	-
After	4 [2–4]	2 [1–4]	4 [2–5.25]	0.310	-
Pre-post treatment difference	0 [0–1]	0 [0–0.25]	0 [0–1]	0.831	-
P2	0.077	0.158	0.020*
The week when the treatment effect is felt	3 [2–3]	4 [2.75–4]	3 [2–3]	0.229	-

Data are presented as mean ± standard deviation, number (%), or median [interquartile range].

*P < 0.05.

^aSignificantly different from the vaginal estradiol group. No significant difference was found in other binary comparisons.

P¹: Comparison result among groups.

P²: Comparison result between pre-treatment and post-treatment in a group.

P³: Age-adjusted comparison result among groups.