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. 2021 Apr 23;12:624290. doi: 10.3389/fgene.2021.624290

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Copyright © 2021 Sharifi and Yasui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MeCP2 protein isoforms. MeCP2e1 and MeCP2e2 protein isoforms are produced from alternative splicing events. The MeCP2e1 isoform is translated from splicing of exon 1 to exons 3 and 4 with the translational start ATG in exon 1. The MeCP2e2 protein isoform is produced from a transcript from all four exons with a translational start ATG in exon 2. Interestingly, this transcript may encode a small peptide from an ORF in exons 1 and 2. (A) MECP2/Mecp2 exon splicing. (B) MeCP2-e1 isoform. (C) MeCP2-e2 isoform.