Figure 3.

Schematic overview of the main signaling pathways modulated by lipoxins and their effects in the pathologies addressed in this review. LXs have been described to coordinate a wide range of signaling pathways depending on cell context, allowing for a fine-tune regulation of the resolution process. For example, they induce apoptosis in neutrophils to promote their clearance while they prevent apoptosis in cardiomyocytes thus exhibiting cardioprotective actions. By modulating different pathways, LXs can exert protective effects on different cell types and environments, as observed by their effects on the brain, heart, lung, liver, periodontium and joints. Mediators highlighted in red indicate downregulation or inhibition by LX action whereas green indicates upregulation or activation.