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. 2021 Apr 23;15:659843. doi: 10.3389/fncel.2021.659843

Figure 1.

Figure 1

Localization of microglia across the various layers of the retina. (A) Vertical section of the adult Cx3CR1+/GFP mouse retina showing a reporter labeled microglial cell (green, EGFP) extending processes from the outer retina (OPL) to the inner retina (IPL). The section was also immunolabeled for the synapse (ribbon) marker, ribeye (red), while nuclei were visualized with bisbenzimide (blue). A second microglia cell (green) is located within the (GCL). (B) Vertical section of the human immunolabeled for the microglial marker, IbA1 (green) and calretinin (red). Nuclei are labeled with bisbenzimide (blue). The microglial cell is a large cell that extends processes into both the inner and outer retina where is contacts synapses. (C) Vertical section of monkey retina immunolabeled for microglia (IbA1, green) and a combination of the synapse marker, ribeye and the neuronal marker calbindin (red). Abbreviations: ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale 20 μm.