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. 2021 Apr 23;11:639108. doi: 10.3389/fcimb.2021.639108

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Copyright © 2021 Ding, Long, Yuan, Jin, Yang, Chen, Chen and Duan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of CRISPR/Cas systematic elimination of SARS-CoV-2. (1) SARS-CoV-2 targets the ACE2 receptor to release viral RNA into cells. (2) After reverse transcription of the viral RNA to form dsDNA, the pre-designed sgRNA-Cas9 identified and specifically cleaved the viral DNA. (3) For Cas13 the system can directly identify and eliminate viral RNA. (4) The CRISPR/Cas system eliminates the SARS-CoV-2 gene, thus making the viral RNA unable to replicate and the viral gene unable to be expressed, and eventually making SARS-CoV-2 unable to replicate.