Table 2.

Summary of the CRISPR/Cas platform for SARS-CoV-2 detection.

Detection platforms	CRISPR/Cassystem	Limit of detection	Time	Characteristics	References
CREST	Cas13a	10copies/μL	30-50min	Combined with RT-PCR technology, CRISPR detection is stable. However, there may be drawbacks to field detection.	(Rauch et al., 2020)
SHERLOCK	Cas13a	42 copies per reaction	70min	Combination of RT-RPA amplification and lateral flow assay for rapid field testing.	(Patchsung et al., 2020)
SHINE	Cas13a	10copies/μL	50min	Improved sample pre-processing (HUDSON) combined with a one-step SHERLOCK for fast field inspection.	(Arizti-Sanz et al., 2020)
DETECTR	Cas12a	10copies/μL	45min	Combined with LAMP to solve the problem of unstable RPA amplification enables faster and more sensitive detection in the field.	(Broughton et al., 2020a)
STOPCovid	Cas12b	100 copy per reaction	<60min	Integrated LAMP and Cas12b detection enables one-step detection, making it easier and faster to operate.	(Joung et al., 2020)
CARMEN	Cas13a	attomolar	NA	Enables large-scale pathogen detection and simultaneous identification of 165 human-associated viruses.	(Ackerman et al., 2020)