Table 1.
Neurotransmitter receptor densities (fmol/mg protein) in different regions of the mouse olfactory system (Mean ± SEM).
| Receptor (fmol/mg protein) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AMPA | Kainate | NMDA | NMDA | mGlu2/3 | GABAA | GABAA(BZ) | GABAB | α1 | α2 | D1/5 | |
| Main olfactory bulb | 727 ± 54 | 1,281 ± 95 | 954 ± 158 | 954 ± 158 | 2,180 ± 121 | 803 ± 93 | 3,867 ± 577 | 2,144 ± 119 | 547 ± 33 | 497 ± 32 | 61 ± 6 |
| Accessory olfactory bulb | 909 ± 88 | 1,328 ± 94 | 1,203 ± 156 | 1,203 ± 156 | 3,948 ± 376 | 950 ± 212 | 6,409 ± 664 | 3,617 ± 288 | 675 ± 50 | 547 ± 69 | 100 ± 15 |
| Anterior olfactory cortex | 1,044 ± 87 | 1,432 ± 69 | 1,445 ± 189 | 1,445 ± 189 | 2,365 ± 165 | 566 ± 73 | 2,038 ± 181 | 4,223 ± 345 | 338 ± 19 | 1,809 ± 160 | 171 ± 29 |
| Taenia tecta, dorsal | 1,151 ± 58 | 1,356 ± 124 | 1,878 ± 213 | 1,878 ± 213 | 2,977 ± 212 | 906 ± 64 | 3,662 ± 331 | 4,736 ± 428 | 308 ± 36 | 1,589 ± 141 | 357 ± 49 |
| Taenia tecta, ventral | 1,361 ± 86 | 1,022 ± 114 | 1,716 ± 125 | 1,716 ± 125 | 2,825 ± 222 | 788 ± 85 | 3,214 ± 272 | 4,316 ± 442 | 321 ± 45 | 1,377 ± 177 | 315 ± 90 |
| Dorsal peduncular cortex | 1,069 ± 62 | 1,624 ± 95 | 1,909 ± 255 | 1,909 ± 255 | 3,442 ± 155 | 1,048 ± 78 | 4,125 ± 340 | 5,048 ± 674 | 317 ± 52 | 1,031 ± 94 | 360 ± 44 |
| Endopiriform nucleus (dorsal) | 789 ± 51 | 1,480 ± 75 | 1,239 ± 129 | 1,239 ± 129 | 1,836 ± 224 | 695 ± 61 | 2,791 ± 257 | 4,059 ± 211 | 238 ± 23 | 1,032 ± 49 | 888 ± 95 |
| Piriform cortex | 1,060 ± 41 | 785 ± 48 | 1,821 ± 162 | 1,821 ± 162 | 3,328 ± 207 | 1,034 ± 68 | 3,961 ± 243 | 4,853 ± 158 | 448 ± 40 | 1,027 ± 80 | 242 ± 28 |
| Entorhinal cortex, lateral | 1,664 ± 59 | 1,054 ± 32 | 3,037 ± 224 | 3,037 ± 224 | 3,070 ± 198 | 1,297 ± 84 | 3,627 ± 221 | 5,894 ± 254 | 314 ± 19 | 1,771 ± 137 | 345 ± 26 |
| Entorhinal cortex, medial | 1,580 ± 102 | 1,040 ± 71 | 2,091 ± 301 | 2,091 ± 301 | 3,081 ± 268 | 1,190 ± 98 | 3,553 ± 487 | 6,201 ± 200 | 304 ± 26 | 1,770 ± 136 | 330 ± 17 |
| Orbitofrontal cortex, medial | 1,089 ± 83 | 1,095 ± 164 | 2,292 ± 278 | 2,292 ± 278 | 3,867 ± 360 | 1,553 ± 105 | 4,894 ± 323 | 5,925 ± 392 | 502 ± 38 | 650 ± 22 | 175 ± 43 |
| Orbitofrontal cortex, ventrolateral | 1,034 ± 79 | 995 ± 140 | 2,101 ± 236 | 2,101 ± 236 | 4,024 ± 511 | 1,520 ± 162 | 4,762 ± 406 | 5,909 ± 461 | 495 ± 48 | 570 ± 24 | 131 ± 28 |
| Orbitofrontal cortex, lateral | 1,100 ± 75 | 1,039 ± 175 | 2,168 ± 209 | 2,168 ± 209 | 3,983 ± 524 | 1,393 ± 172 | 4,269 ± 529 | 5,003 ± 404 | 513 ± 67 | 564 ± 22 | 211 ± 33 |
| Olfactory tubercle | 1,079 ± 88 | 964 ± 70 | 1,638 ± 131 | 1,638 ± 131 | 3,964 ± 346 | 853 ± 77 | 3,048 ± 403 | 2,995 ± 277 | 204 ± 25 | 770 ± 107 | 5,340 ± 439 |
| Friedman ANOVA(χ2), | 85.531*** | 78.060*** | 82.983*** | 82.983*** | 79.952*** | 93.630*** | 70.971*** | 94.811*** | 102.14*** | 105.714*** | 106.140*** |
| ***p <0.001 | |||||||||||
The Friedman ANOVAs display regional differences for each receptor type (all N = 10, df = 13). For pairwise comparisons between regions see further Supplementary Table 2.