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. 2021 Apr 23;12:650536. doi: 10.3389/fgene.2021.650536

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Copyright © 2021 Zhang, Gao, Lin, Xiong, Wang, Chen, Lin and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomal miRNAs targeting regulated DEGs. (A,B) Exosomal miRNAs with identical differential expression in ACLF liver samples were screened as candidate DEmiRs. The Venn diagram shows the number of up- vs. down-regulated miRNAs. The miRNA screening criteria used was |logFC| ≥ 1, p ≤ 0.05. (C,D) The number of DEmiRs targeting genes differentially expressed in the transcriptome. The transcriptome screening criteria was |logFC| ≥ 2, p ≤ 0.05. (E,F) The number of DEmiRs target genes that are differentially expressed in the proteome. DEmiRs: differentially expressed miRNAs.