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. 2021 Apr 23;12:650536. doi: 10.3389/fgene.2021.650536

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Copyright © 2021 Zhang, Gao, Lin, Xiong, Wang, Chen, Lin and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hBMSCs inhibit liver inflammation via the miR-20a-5p/CXCL8 axis. The intracellular levels of miR-20a-5p in hepatocytes increase after the uptake of miR-20a-5p-rich exosomes. In turn, miR-20a-5p inhibits the expression of CXCL8 (together with RISC), resulting in reduced CXCL8 secretion. hBMSCs not only secrete miR-20a-5p-rich exosomes directly into the hepatic microenvironment but also may promote the endogenous synthesis of miR-20a-5p in hepatocytes and its secretion as exosomes via other pathways. The accurate detection of miR-20a-5p and its precursors is required to prove the latter hypothesis. RISC, RNA-induced silencing complex.