Table 1.

Study assessments and timing

Domain	Assessment	Time point	Rationale
Questionnaires	Demographics	D0	To be used in multivariate analysis
	Medical history	D0	To be used in multivariate analysis
	Household risk factors	D0	To be used in multivariate analysis
	Medications	D0, D28, D60	To be used in multivariate analysis
	Exposure history	D0, D7, D14, D21, D28, D60	To be used in multivariate analysis
	Symptoms/adverse events	D0, D7, D14, D21, D28, D60	Monitor safety
	COVID-19-related event reporting	D7, D14, D21, D28, D60	To be used in multivariate analysis
	Adherence to treatment	D7, D14, D21, D28	To be used in multivariate analysis
	Study arm (patients’ self-assessment of to which arm they were randomised)	D28	To be used in multivariate analysis
Microbiota	Stool collection (OMNIgene-GUT kit)	D0, D7, D28	Gut microbiota analysis
	Nasal swab collection	D0, D7, D28	COVID-19 infection status