Figure 8.

A, liver acetate generation was stimulated by CFB or DCA₁₂treatment and reduced by TDYA in the fasting rats. Mean ± SEM, n = 8, ∗p < 0.05 by t-test between paired conditions. B, generation of acetate and acetyl-carnitine with C₁₂-CoA, DC₁₂-CoA or acetyl-CoA as a substrate by isolated peroxisomes. Mean ± SEM, n = 6, ∗p < 0.05 by t-test between paired conditions. C, peroxisomal activity of ACOT12 was increased in the livers of the fasting rats. D, gene expression of liver ACOT12 was upregulated by fasting. Mean ± SEM, n = 8, ∗p < 0.05 by t-test between paired conditions.