Figure 2.

ChREBP mediates G6P homeostasis. Sugar consumption particularly with sugars containing fructose increases hepatocellular hexose-phosphate levels including G6P. G6P or a closely related metabolite activates ChREBP, which transactivates expression of enzymes involved in G6P disposal. This includes enzymes of glycolysis such as Pklr and enzymes of de novo lipogenesis including ACC and FASN. This also includes enzymes involved in glucose production such as G6PC. Catabolism of G6P either via glycolysis or glucose production reduces G6P inhibiting ChREBP and returning the system to a homeostatic equilibrium. Enzymes noted in red are ChREBP transcriptional targets.