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. 2021 Apr 23;12:658811. doi: 10.3389/fphar.2021.658811

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Copyright © 2021 Wang, Tang, Liang, Jin, Gao, Li, Li, Shao, Zhang, Tan, Zhang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YQJPF inhibited necroptosis of LPS- and D-Gal-treated hepatocytes in vitro. Human LO2 cells were treated with LPS + D-Gal for 4 h and further with YQJPF and atractylone. (A–D) Real-time PCR analyses of genes of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, and IL-18. (E) Western blot analysis and quantitative analysis of the expression of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, and IL-18 (F–I) Expression levels of IL-1β, IL-6, TNF-α, and IL-18 in LO2 were detected by ELISA. Data are expressed as mean ± SD (n = 3). *vs. control group, ^#vs. LPS + D-Gal group; *p < 0.05, **p < 0.01; ^# p < 0.05, ^## p < 0.01.