Table 2.
Example of proteins function affected by glutathionylation and recognized or possible target of Grx regulation.
| Proteins regulated by glutathionylation | Glutathionylation Induced Functional Changes |
|---|---|
| GAPDH# [[53], [54], [55]] | Inhibition |
| NF-kB# [[56], [57]] (p65 [[58], [59]]; P50 [60]) | Inhibition |
| PTP1B# [61] | Inhibition |
| c-Jun [[62], [63]] | Inhibition |
| Rac-1 [[64], [65]] | Inhibition |
| Creatine kinase# [[66], [67]] | Inhibition |
| Actin# [[68], [69], [70], [71]] | Activation |
| Akt# [[72], [73]] | inhibition |
| Fas (CD95; Apo-1) #[74] | Activation |
| AMPK# [[75], [76]] | Activation |
| Estrogen receptor alpha [77] | Inhibition |
| Catalase [78] | inhibition |
| Ryanodine receptor 2# [[79], [80]] | Activation |
| Complex I # [81] | inhibition |
| Sirtuin-1# [[82], [83]] | Inhibition |
| Mitofusin [84] | Activation |
| IKK-Beta# [85] | Inhibition |
# Grx is reported to regulate the glutathionylation.