Table 2. Baseline hypersensitivity characteristics (n = 214).
| Characteristic | Value | |
|---|---|---|
| Inciting NSAID with documented history of hypersensitivity | ||
| Aspirin | 141 (65.9) | |
| Acetic acids | 47 (22.0) | |
| Propionic acids | 28 (13.1) | |
| Fenamic acids | 25 (11.7) | |
| Coxibs | 7 (3.3) | |
| Pyrazolones | 3 (1.4) | |
| Oxicams | 1 (0.5) | |
| Unknown NSAID | 9 (4.2) | |
| Type of index reaction to NSAID | ||
| Angioedema | 104 (48.6) | |
| Rash | 65 (30.4) | |
| Urticaria | 11 (5.1) | |
| Respiratory symptoms | 7 (3.3) | |
| Itch | 7 (3.3) | |
| Anaphylaxis | 1 (0.5) | |
| Skin swelling | 1 (0.5) | |
| Near syncope | 1 (0.5) | |
| Others* | 5 (2.3) | |
| Unknown reaction | 47 (22.0) | |
| No. of non-NSAID drugs with documented hypersensitivity | 0 (0–4) | |
| Hypersensitivity to ≥ 1 non-NSAID drugs | 89 (41.8) | |
| Type of non-NSAID drugs with documented hypersensitivity | ||
| Antibiotics and related compounds† | 47 (52.8) | |
| Pain management agents | 37 (41.6) | |
| Cardiovascular drugs | 9 (10.1) | |
| Antihistamines | 7 (7.9) | |
| Stimulants | 6 (6.7) | |
| Asthma management agents | 3 (3.4) | |
| Others | 18 (20.2) | |
| Type of reaction to the non-NSAID drugs | ||
| Rash | 27 (30.3) | |
| Angioedema | 20 (22.5) | |
| Anaphylaxis | 4 (4.5) | |
| Respiratory symptoms | 1 (1.1) | |
| Pruritus | 1 (1.1) | |
| Skin swelling | 1 (1.1) | |
| Others | 2 (2.2) | |
| Unknown reaction | 51 (57.3) | |
| No. of previous aspirin desensitization | 0 (0–2) | |
| Reaction to aspirin in the past 1 year prior to desensitization | 27 (12.6) | |
Values are presented as number (%) or median (range).
NSAID, nonsteroidal anti-inflammatory drug.
*Includes fever, giddiness, stomach-ache, teary eyes, palpitations. †Includes clavulanic acid.