Table 4. Multivariate analysis of association between patient characteristics and failure of aspirin desensitization.
| Variable | All patients (n = 214) | Selected sample† (n = 163) | |||
|---|---|---|---|---|---|
| Adjusted OR | 95% CI | Adjusted OR | 95% CI | ||
| Inciting NSAID with documented hypersensitivity | |||||
| Aspirin | 1.15 | 0.53–2.48 | 1.15 | 0.47–2.83 | |
| Propionic acid | 2.27 | 0.84–6.10 | - | - | |
| Acetic acid | - | - | 2.03 | 0.80–5.15 | |
| Type of NSAID reaction | |||||
| Rash | 0.80 | 0.32–1.95 | 0.92 | 0.32–2.66 | |
| Angioedema | 5.88 | 2.60–13.30* | 7.21 | 1.94–26.71* | |
| Comorbidities | |||||
| Atopic disease | 3.13 | 1.16–8.42* | 2.27 | 0.71–7.29 | |
| Diabetes mellitus | - | - | 0.50 | 0.19–1.34 | |
| Reaction to aspirin in the past 1 year prior to aspirin desensitization | 0.40 | 0.12–1.30 | 0.47 | 0.14–1.58 | |
OR, odds ratio; CI, confidence interval; NSAID, nonsteroidal anti-inflammatory drug.
*p < 0.05, statistically significant differences. †Excluded patients who have unknown reactions to NSAIDs (n = 47) or reactions not suggestive of hypersensitivity to NSAIDs (n = 4).