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. 2021 Apr 23;12:665416. doi: 10.3389/fgene.2021.665416

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Copyright © 2021 Wang, Ma, Xie, Wu, Wang, Duan, Zhang, Yu, Guo and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complex biological processes of luminal B and basal-like subtype. We mapped the genes and miRNAs obtained from luminal B's module and basal-like's module to an integrated gene regulation network. The network was obtained through integrating three databases including Reactom, Kyoto Encyclopedia of Genes and Genomes, and Nci-PID Pathway Interaction Database. The interactions between genes and miRNAs were obtained from miRTarBase. The size of the node is proportional to the size of the degree. The thickness of the edges indicates the strength of the regulatory relationship expressed by the Pearson correlation coefficient between microRNA and gene.