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. 2021 Apr 23;12:665416. doi: 10.3389/fgene.2021.665416

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Copyright © 2021 Wang, Ma, Xie, Wu, Wang, Duan, Zhang, Yu, Guo and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Part of complex biological processes luminal B and basal-like. The edges with checkmarks are the interactions that have been documented. (A) Luminal B's biological processes: luminal subtypes are driven by the estrogen/ER pathway. Among all nodes, ERBB2, ERBB3, and ESR1 are involved in the estrogen/ER pathway. (B) Basal-like's biological processes: basal-like subtype is driven by the deregulation of various signaling pathways (Notch, MAPK, FoxO signaling pathway, and Wnt/beta-catenin). Among all nodes, MAPKAPK2, CDC25B, CCNB1, CCNB2, PAK1, and STMN1 are known to exist in multiple signaling pathways.