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. 2021 Apr 23;12:665416. doi: 10.3389/fgene.2021.665416

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Copyright © 2021 Wang, Ma, Xie, Wu, Wang, Duan, Zhang, Yu, Guo and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier (K–M) survival analysis for patients which are classified using different methods. (A) KM survival curve for labeled samples, whose subtypes are known in advance. (B) KM survival analysis for unlabeled samples, which are classified using complex biological processes–joint matrix tri-factorization (CBP-JMF) on mRNA expression and miRNA expression data. (C) KM survival analysis for unlabeled patients, which are classified using CBP-JMF only on mRNA expression. (D) KM survival analysis for unlabeled patients, which are classified on mRNA expression and miRNA expression data without graph embedding regularization.