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. 2021 Mar 2;7(1):80–94. doi: 10.3390/tomography7010008

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Imaging unilateral urinary obstruction in mice using Imidazole CEST MRI agent; (A) Imidazole-4,5-dicarboxamide-di Glutamate (I45DC-diGlu) structure; (B) Experimental MTR_asym spectra for I45DC-diGlu as a function of pH t_sat = 3 s, ω₁ = 6.0 μT, 37 °C; (C) in vivo kidney images; Experimental conditions: t_sat = 3 s, ω₁ = 6.0 μT. Dynamic CEST images were acquired using the same 2 offset CEST protocol described in Figure 6 for Iopamidol. Two CEST images at offsets 4.3 and 7.5 ppm were acquired repeatedly for a total time of 76 min and 10 set of M0 images at offset 40 ppm were collected. Time interval between two dynamic CEST images was 44 s; (D) Average parenchymal contrast for obstructed and non-obstructed kidney.