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Summary of the chemical and physical crosslinking methods in nanogels (NG) design. (A) The formation of covalent bonds (crosslinking points, in red) between the reactive moieties (yellow and green) of polymers X and Y can be addressed through different chemical reactions exploiting the nature of the reacting groups. (B) The physical interactions between polymers W and Z enables the formation of a self-assembled nanoscaffold.
