Table 2.
The use of PHSRN peptides to enhance bone regeneration. ↑ = increase, ↓ = decrease, ≈ = no change, - = not reported.
| Peptide Sequence + Additional Bioactive Components |
Attachment Methodology | Substrate | Cell Type | In Vitro Attachment | In Vitro Spreading | In Vitro Differentiation | In Vitro Mineralisation | In Vivo Efficacy | Publication |
|---|---|---|---|---|---|---|---|---|---|
| PHSRN | Adsorption | Titanium | SAOS-2 | ≈ | ≈ | ≈ | - | - | [47] |
| CGGPHRSN | Silanisation | Titanium | RBMSC | ↑ | ↑ | - | - | - | [56] |
| RGD + PHSRN | Adsorption | Titanium | SAOS-2 | ↑ | ↑ | ≈ | - | - | [47] |
| RGD + PHSRN | Adsorption | Titanium | SAOS-2 | ↑ | ↑ | ≈ | - | - | [47] |
| GRGD + G13 + PHSRN | Adsorption | PS | BMSC | ↑ | - | ↑ | - | - | [95] |
| CGGRDGS + CGGPHSRN | Silanisation | Titanium | RBMSC | ↑ | ≈ | - | - | - | [56] |
| GRGD + G13 + PHSRN | Carbodiimide | SAMs | MC3T3-E1 | ↑ | - | - | - | - | [96] |
| GRGD + G13 + PHSRN | Hydrogel | PEG | RCO | ↑ | ↑ | ↑ | ↓ | - | [29] |