Table 7.
The use of peptide combinations to enhance bone regeneration. ↑ = increase, ↓ = decrease, ≈ = no change, - = not reported.
| Peptide Sequence + Additional Bioactive Components |
Attachment Methodology | Substrate | Cell Type | In Vitro Attachment | In Vitro Spreading | In Vitro Differentiation | In Vitro Mineralisation | In Vivo Efficacy | Publication |
|---|---|---|---|---|---|---|---|---|---|
| RGD + FHRIKKA | |||||||||
| GPenGRGDSPCA + (G7 or E7)FHRRIKA |
Adsorption | HA | HMSC | ↑ | ≈ | - | - | - | [38] |
| CGGRDGS + CGGFHRRIKA | Silanisation | Titanium | RBMSC | ↑ | ↑ | - | - | - | [56] |
| CGGNGEPRGDTYRAY + CGGFHRRIKA | Silanisation | Quartz | RCO | ↑ | ↑ | - | ↑ | - | [55] |
| CGGNGEPRGDTYRAY + CGGFHRRIKA | Carbodiimide | Hydrogel | RCO | ↑ | - | - | - | - | [129] |
| RGD + KRSR | |||||||||
| GPenGRGDSPCA and (G7 or E7)KRSR |
Adsorption | HA | HMSC | ↑ | ≈ | - | - | - | [38] |
| RGDS + KRSRGGG | Silanisation | Glass | RCO | ↑ | - | - | - | - | [87] |
| KRSRG3 | Hydrogel | C2SH48C2 | MG63 | ↑ | - | - | - | - | [79] |
| RGD + KRSR | Silanisation | Titanium | SAOS2 | ↑ | ↑ | - | ↑ | - | [86] |
| RGD + BMP Mimetic | |||||||||
| GGRGDS + KIPKASSVPTELSAISTLYL | Silanisation | Glass | HMSC | ↑ | ↑ | ↑ | - | - | [54] |
| GGRGDS + KIPKASSVPTELSAISMLYL | Carbodiimide | PET | MC3T3-E1 | ↑ | - | ↑ | ↑ | - | [90] |
| RTVPKPSSAPTQLNAISTLYF | Carbodiimide | PET | MC3T3-E1 | ↑ | - | ↑ | ↑ | - | [90] |
| RKVGKASSVPTKLSPISILYK | Carbodiimide | PET | MC3T3-E1 | ↑ | - | ↑ | ↑ | - | [90] |
| GRGDSPC + RKIPKASSVPTELSAISMLYL | Carbodiimide | PET | HMSC | ↑ | ↑ | - | ↑ | - | [91] |
| GGRGDS + KIPKASSVPTELSAISTLYL | Click-chemistry | SAMs | BMSC | ↑ | ↑ | - | ↑ | - | [71] |
| GGRGDS + KIPKASSVPTELSAISTLYL | Click-chemistry | Hydrogel | RBMSC | ↑ | - | ↑ | ↑ | - | [70] |
| FHRIKKA + KRSR + BMP Mimetic | |||||||||
| CFHRRIKA + CKRSR + NSPVNSKIPKACCVPTELSAI | Carbodiimide + Layer-by-Layer | PLGA/HA | RBMSC | ↑ | ↑ | ↑ | ↑ | ↑ | [128] |
| GFHRRIKA + RKIPKASSVPTELSAISMLYL | Carbodiimide | PET | HMSC | ↑ | ↑ | - | ↑ | - | [91] |