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. 2021 Apr 23;11:653222. doi: 10.3389/fonc.2021.653222

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Copyright © 2021 Zhu, Li, Yuan, Dong and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of CG locus in APC promoters in gastric and hepatic cancers. Promoter 1A (chr5: 112072720–112073585, GRCh37/hg19) is located at approximately 30.4 kb in the downstream region of promoter 1B (chr5: 112043008–112043594, GRCh37/hg19) of the APC gene. The colored lollipops denote statistically significant hypermethylated CG loci associated with prognosis, while the blue color indicates good prognosis, and the orange color means poor prognosis in gastric cancer; the red indicates poor prognosis in hepatic cancer [the colored lollipops referring to CG locus from left to right are cg04011030, cg18315896, cg08934600, cg18536802, cg08512345, cg25922032 (promoter 1B); cg00577935, cg14511739, cg14479889, cg16970232, cg23938220, cg02511809 (promoter 1A)]. Illustrator of biological sequences (IBS) was used to create the illustration.