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. Author manuscript; available in PMC: 2021 May 7.
Published in final edited form as: Sci Signal. 2019 Dec 3;12(610):eaav5918. doi: 10.1126/scisignal.aav5918

Fig. 8. Exogenous eicosanoids and small molecule inhibitors of cPLA2α and FLAP alter the migration velocity of dermal fibroblasts.

Fig. 8.

(A) Migration velocity of pDFs from WT and cPLA2α mice treated with ethanol or the indicated concentrations of PGE2, 5-HETE, or 20-HETE. (B) Migration velocity of pDFs from KO mice treated with increasing concentrations of 5-HETE. (C–E) Migration velocity of pDFs from WT, KI, and KO mice in the presence of pyrrophenone (C), MK886 (D), or the indicated combinations of pyrrophenone, MK886, and 5-HETE (E). Samples were compared using ANOVA followed by Tukey’s post-hoc test. Data shown are means ± SD, n = 3–10 cell isolates per genotype (3–8 mice per genotype were used to generate the cell isolates) for each treatment group. *P< 0.05, **P< 0.01, ***P< 0.001, ****P< 0.0001.