Figure 3.

Composite outcomes comparing the pathway with the historical cohort. Data depicted as number of pregnancies. *GEE model adjusted for predefined confounders: history of lupus nephritis, thromboembolic events, pre-eclampsia and the number of miscarriages.†GEE model adjusted for predefined confounders: lupus nephritis and EULAR/ACR criteria. ‡Crude OR was presented: the small number of events did not allow adjustment for confounders in the separate analysis of the patients with primary APS. §Composite outcome including miscarriage, gestational hypertension and severe hypertensive disease.¶Composite outcome including perinatal death, fetal growth restriction, congenital heart block, preterm birth <37 weeks, NICU admission. ACR, American College of Rheumatology; EULAR, European League Against Rheumatism; GEE, Generalised Estimating Equations; NICU, neonatal intensive care unit.