Table I.
Comparisons between patients with and without a final diagnosis of celiac disease
| Variable | CD group (n = 4) | Non-CD group (n = 126) | p-value |
|---|---|---|---|
| Symptoms, n (%) | |||
| Diarrhea | 3 (75) | 9 (7.1) | < 0.001 |
| Constipation | 1 (25) | 6 (4.8) | 0.077 |
| Fatigue | 2 (50) | 19 (15) | 0.062 |
| Weight loss | 1 (25) | 11 (8.7) | 0.268 |
| Dyspepsia | 4 (100) | 36 (28.6) | 0.002 |
| Nausea/vomiting | 1 (25) | 4 (3.2) | 0.025 |
| Abdominal pain | 3 (75) | 30 (23.8) | 0.021 |
| Bloating | 2 (50) | 20 (15.9) | 0.073 |
| Recurrent oral aphthosis | 4 (100) | 11 (8.7) | < 0.001 |
| Atopy | 1 (25) | 0 (0) | < 0.001 |
| Laboratory tests | |||
| Positive AEA, n (%) | 4 (100) | 1 (0.8) | < 0.001 |
| Positive AGA, n (%) | 2 (50) | 2 (1.6) | < 0.001 |
| HLA-DQ2, n (%) | 1 (25) | 4 (3.2) | 0.025 |
| HLA-DQ8, n (%) | 4 (100) | 9 (7.1) | < 0.001 |
| Total IgA [mg/dl] | 230.5 | 130.2 | 0.049 |
| ESR [mm/h] | 20.67 | 10.99 | 0.023 |
| CRP [mg/l] | 11.33 | 4.69 | 0.028 |
| Creatinine [mg/dl] | 1.03 | 1 | 0.6 |
| Hb [g/dl] | 9.87 | 11.88 | 0.004 |
| Platelets [count/mm3] | 206 × 103 | 193 × 103 | 0.418 |
Statistically significant comparisons are indicated in bold. AEA – anti-endomysium antibodies, AGA – anti-gliadin antibodies, CD – celiac disease, CRP – C-reactive protein, ESR – erythrocyte sedimentation rate, Hb – hemoglobin, HLA – human leukocyte antigen.