Skip to main content
. 2021 Mar 15;104(5):1820–1829. doi: 10.4269/ajtmh.20-1481

Table 3.

Characteristics of molecular analysis reported by published therapeutic efficacy reports on artemisinin-based combination therapy from sub-Saharan Africa

n N %
Study shows genotyping data* 6 232 3
Study cites the 2007 WHO genotyping methodology 41 129 32
Study explicitly states how samples with multiple alleles were analyzed 97 232 42
 Consistent with the WHO methodology 74 97 76
 Inconsistent with the WHO methodology 14 97 14
 Unclear 9 97 9
Study specifies how fragment lengths were measured
 Capillary sequencing 9 232 4
 Gel electrophoresis 49 232 21
 Not specified 174 232 75
Study specifies whether all loci were analyzed or if sequential approach was used§
 All loci systematically assayed 2 201 1
 Sequential 23 201 11
 Not specified 176 201 88

N = number of articles assessed; n = number of articles with a finding.

*

Does not include two additional studies with example, illustrative genotyping data.

Among articles conducted after 2009.

Among studies using fragment length polymorphic sites.

§

Among studies analyzing more than one locus.