Table 5.

Statistical methods for analysis of new infections in therapeutic efficacy studies from sub-Saharan Africa

		Exclude		Treat as ACPR		Unclear
	N	n	%	n	%	n	%	P-value*
Study region
West Africa	73	11	15	44	60	18	25	0.0003
Central Africa	32	16	50	14	44	2	6
East Africa	53	19	36	31	58	3	6
Southern Africa	17	7	41	10	59	0	0
Study explicitly describes statistical methods
Yes	38	20	53	17	45	1	3	0.0002
No	159	33	21	101	64	25	16
Study presents the Kaplan–Meier estimate
Yes	57	34	60	20	35	3	5	< 0.0001
No	140	19	14	98	70	23	16
Study cites the WHO protocol
Yes	172	53	31	97	56	22	13	0.0049
No	25	0	0	21	84	4	16

ACPR = adequate clinical and parasitological response; N = number of articles assessed; n = number of articles with a finding.

^*Difference between rates of studies excluding or reclassifying as ACPR, calculated using chi-squared test.