Table 2.

International Club of Ascites (ICA-AKI) new definitions for the Diagnosis and Management of AKI in Patients with cirrhosis.

Subject	Definition
Baseline sCr	A value of sCr obtained in the previous 3 months, when available, can be used as baseline sCr. In patients with more than one value within the previous 3 months, the value closest to the admission time to the hospital should be used.
	In patients without a previous sCr value, the sCr on admission should be used as baseline.
Definition of AKI	•Increase in sCr SO.3 mg/dl ($\ge$26.5 μmol/l) within 48 h; or, •A percentage increase sCr $\ge$50% from baseline which is known, or presumed, to have occurred within the prior 7 days
Staging of AKI	•Stage 1: increase in sCr $\ge$0.3 mg/dl (26.5 μmol/l) or an increase in sCr $\ge$1.5-fold–2-fold from baseline •Stage 2: increase in sCr >twofold–3-fold from baseline •Stage 3: increase of sCr >threefold from baseline or sCr $\ge$4.0 mg/dl (353.6 μmol/l) with an acute increase $\ge$0.3 mg/dl (26.5 μmol/l) or initiation of RRT
Progression of AKI	Progression	Regression
	Progression of AKI to a higher stage and/or need for RRT	Regression of AKI to a lower stage
Response to treatment	No response	Partial response	Full response
	No regression of AKI	Regression of AKI stage with a reduction of sCr to $\ge$0.3 mg/dl (26.5 μmol/l) above the baseline value	Return of sCr to a value within 0.3 mg/dl (26.5 μjmol/L) of the baseline value

AKI, acute kidney injury; RRT, renal replacement therapy; sCr, serum creatinine.