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. 2021 Apr 23;8:652746. doi: 10.3389/fcvm.2021.652746

Figure 4.

Figure 4

Methionine and deoxyuridine (dU)-related pathways in plasma. (A) Methionine (Met) abundance-related pathway in plasma. (B) The Met-related enzyme MTR is significantly* decreased and CBS is significantly higher in MI cases (n = 31) compared with healthy individuals (n = 21). (C) The Met-related enzyme MetRS(MARS2) abundance in the myocardium of murine MI models (n = 36) is downregulated* compared with control (n = 23), while human plasma MetRS remains unchanged. (D) dU-centered metabolism in plasma cells. (E) dU-related enzymes CDA, UPB1, and UPP1 are significantly* higher in the MI group (n = 31) plasma compared with those in healthy individuals (n = 21). (F) dU-related intermediates uracil, uridine, and dCMP significantly* dropped in MI cases (n = 85) compared with those in healthy individuals (n = 84). (G) Neutrophils, monocytes, lymphocytes, and white cell counts of non-MI cases (n = 34) and MI cases (n = 74). (H) dU is significantly* higher in the NT-proBNP(+) group (n = 104) than in the NT-proBNP(–) group (n = 29). (A,D): red indicates upregulated metabolites or enzymes, blue indicates the downregulated, black indicates the unchanged, and gray indicates undetected metabolites. *Student's t-test, p < 0.05.