Figure 2.

Continuous associations of fibrotic-like patterns with admission Sequential Organ Failure Assessment (SOFA) score (top left), lactate dehydrogenase (LDH) levels (top right), duration of mechanical ventilation in days (bottom left) and age-adjusted leucocyte telomere length percentile (bottom right) using generalised additive models with locally weighted smoothing (LOESS). Blue line represents predicted values. Black dashed lines are 95% CIs. Hash marks along the x-axis indicate individual study participants. Since there was no evidence for non-linearity in the generalised additive models, we estimated adjusted ORs using logistic regression models. All models are adjusted for a common set of potential confounders (age, sex, race/ethnicity, days since infection, body mass index, pack-years of smoking, treatment with steroids while hospitalised) and the other independent variables of interest (SOFA score, LDH, days of mechanical ventilation, telomere length). OR for SOFA score is per point increase, for LDH is per 50-point increase, for mechanical ventilation is per day increase, and for telomere length is per 10% decrease in percent-predicted value.