Table 3.
Treatment (Trt) | HIM1 | P-value | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CON | GLU | SEM | −33 | −27 | −21 | −15 | −9 | −3 | SEM | Trt | HIM | Trt × HIM | |
Whole blood | |||||||||||||
O2 mmol/L | 4.42 | 4.49 | 0.18 | 4.40ab | 4.41ab | 4.50ab | 4.79a | 4.52ab | 4.11b | 0.22 | 0.78 | 0.02 | 0.49 |
CO2 mmol/L | 29.4 | 28.9 | 0.87 | 30.2 | 29.1 | 28.9 | 28.8 | 28.8 | 29.1 | 0.87 | 0.68 | 0.59 | 0.86 |
pH | 7.47 | 7.47 | 0.01 | 7.47 | 7.48 | 7.47 | 7.46 | 7.47 | 7.48 | 0.01 | 0.97 | 0.31 | 0.43 |
Na+, mmol/L | 138 | 138 | 0.59 | 139 | 138 | 138 | 138 | 138 | 139 | 0.57 | 0.81 | 0.07 | 0.46 |
K+, mmol/L | 3.91 | 4.15 | 0.10 | 3.93 | 3.98 | 4.02 | 4.10 | 4.07 | 4.08 | 0.09 | 0.13 | 0.18 | 0.74 |
Ca++, mmol/L | 1.22 | 1.21 | 0.02 | 1.23ab | 1.23ab | 1.24a | 1.22ab | 1.20b | 1.20b | 0.01 | 0.66 | <0.001 | 0.16 |
Cl−, mmol/L | 103 | 103 | 1.14 | 103 | 103 | 104 | 104 | 103 | 103 | 0.88 | 0.80 | 0.08 | 0.13 |
Glucose, mmol/L | 4.83 | 4.75 | 0.15 | 4.78 | 4.67 | 4.82 | 4.83 | 4.95 | 4.69 | 0.22 | 0.68 | 0.80 | 0.48 |
l-Lactate, mmol/L | 1.41 | 1.74 | 0.17 | 1.32b | 1.26b | 1.41ab | 1.54ab | 1.97a | 1.94a | 0.19 | 0.20 | <0.001 | 0.64 |
Plasma | |||||||||||||
Glucose, mmol/L | 5.37 | 5.53 | 0.14 | 5.44 | 5.45 | 5.21 | 5.38 | 5.99 | 5.21 | 0.27 | 0.41 | 0.09 | 0.08 |
l-Lactate, mmol/L | 1.45 | 1.78 | 0.15 | 1.40b | 1.38b | 1.40b | 1.42b | 1.95ab | 2.15a | 0.24 | 0.17 | <0.01 | 0.97 |
Urea, mmol/L | 3.07 | 3.36 | 0.27 | 3.32 | 3.43 | 3.21 | 3.17 | 3.03 | 3.12 | 0.25 | 0.46 | 0.45 | 0.89 |
TG2, umol/L | 0.34 | 0.39 | 0.05 | 0.33 | 0.28 | 0.40 | 0.43 | 0.36 | 0.37 | 0.06 | 0.53 | 0.41 | 0.51 |
NEFA, µekv/L | 585 | 370 | 88.8 | 313 | 242 | 554 | 462 | 536 | 759 | 153 | 0.12 | 0.05 | 0.92 |
Insulin, ng/L | 49.5 | 90.4 | — | 71.3 | 96.8 | 56.6 | 49.8 | 105.4 | 43.6 | — | 0.11 | 0.44 | 0.35 |
[9.66;253] | [17.7;463] | [13.9;365] | [18.9;496) | [11.1;290] | [9.73;255} | [20.6;540} | [8.52;223] |
1Samples timepoints are grouped in 6 h intervals from −36 to −31, −30 to −25, −24 to −19, −18 to −13, −12 to −7, and −6 to 0.
2 Triglycerides.
a,bLeast squares treatment means with different superscript letters differ significantly (P < 0.05).