Table 1.
Evaluation of the transmission-blocking activity of different immunization groups in mosquito feeding assays
| Mouse | Immunization group | Oocyst density mean (range) (n = 180) |
TRAa | Prevalence of infection mean (n = 180) | TBAb |
|---|---|---|---|---|---|
| Mouse 1–6 | Control | 130.6 (0–254) | 94.4% (170/180) | ||
| Trx-His | 129.4 (0–254) | 95.6% (172/180) | |||
| Pbg37 | 66.8 (0–224) | 48.4% | 92.2% (166/180) | 3.4% | |
| PSOP25 | 48.7 (0–167) | 62.3% | 82.8% (149/180) | 12.8% | |
| Pbg37+PSOP25 | 32.4 (0–138) | 74.9% | 80.0% (144/180) | 15.6% | |
| Pbg37-PSOP25 | 29.7 (0–140) | 77.0% | 76.1% (137/180) | 19.5% |
aTRA was calculated as (mean oocyst densityTrx-His – mean oocyst density Pbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25) / mean oocyst densityTrx-His × 100%
b TBA was calculated as % prevalenceTrx-His – % prevalencePbg37/PSOP25/Pbg37+PSOP25/Pbg37-PSOP25