Table 3.

Changes in RT plan in studies assessing effect of PSMA PET results on treatment plan

Author and year	N	Inclusion criteria	Median PSA level, ng/mL (range)	Change in planned pelvic RT
				% local plan change	% extra-pelvic disease	local plan change details
Calais et al. 2018 [54]	73	IR/HR PCa prior to RT planning	13.9 (0.22–909)	7–19.5%a	9.5%	covered pelvic LNs detected
Frenzel et al. 2018 [51]	20	PCa prior to RT planning	7.1 (0.48–137)	15%	N/A	shifted from IR to HR, one patient had boost to distant PET findings
Hruby et al. 2018 [55]	109	IR/HR PCa prior to RT planning	9.9 (1.23–240)	14.7%	6.4%	covered pelvic LNs detected
Roach et al. 2017 [44]	108	IR/HR PCa prior to RP/ EBRT/ systemic treatment	8.6 (0.18–120)	15%	9%	higher dose and volume
Sterzing et al. 2016 [62]	15	HR PCa for staging	7 (0.28–45)	13%	N/A	covered pelvic LNs detected

^aDepending on initial intent to include elective pelvic nodal RT (change: 7%) or not (change: 19.5%). ⁺Mean value reported, not median. EBRT external-beam radiotherapy