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Schematic diagram of the mechanism underlying circPIKfyve as a ceRNA for miR-21-3p to regulate MAVS expression. miR-21-3p targets MAVS and represses MAVS-mediated antiviral responses, thereby regulating viral replication. circPIKfyve acts as a molecular sponge regulating miR-21-3p to enhance MAVS expression, thereby maintaining the stable antiviral responses and ensuring appropriate inflammatory responses.
