TABLE 2.

Tideglusib drug levels in plasma during the oral dosing phase^a

Dose (mg/kg/day)	Level (ng/ml)
	Tideglusib						Control
	31041	31096	31100	31831	31098	31132	31293	31315	31500	31153	31254
8.75	<5	10.0	9.0	11.3	4.9	<5	NA	NA	NA	NA	NA
8.75b	<5	<5	<5	<5	<5	<5	NA	NA	NA	NA	NA
20	36.2	14.6	33.8	<5	<5	20.3	<5	<5	<5	<5	<5
40	18.27	<5	<5	<5	<5	<5	<5	<5	<5	<5	<5
80	54.7	21.1	30.8	<5	10.9	7.4	<5	<5	<5	<5	<5

^aSamples were collected at trough following each cycle of daily oral dosing with tideglusib at the indicated doses. Animals are identified by five-digit numbers. The limit of detection was 5 ng/ml. NA, not assayed.

^bAMO-02.