FIG 4.
Absence of IL-4R expression on macrophages does not impair cyclosporine-induced reactivation. (A) Timeline of treatments with cyclosporine (CA) and imaging to measure CA-induced MHV68-M3FL reactivation in mice. Total flux (photons per second) was measured using an Ivis bioluminescence imager. (B) Representative images of Il4rαf/f × LysMcre+ and Il4rαf/f × LysMcre− mice on day 7 after CA treatment. The red circles mark the areas used for total flux measurements. (C) Quantitation of total flux. The data shown are the results obtained from a pool of two independent experiments. Bars represent means ± SD. Each dot represents an individual mouse. ns, not significant; *, P < 0.05; **, P < 0.01; ****, P < 0.001.