Table 3.
Proportion of participants with grade 3 or higher toxicity by body mass index and physical activity
| Treatment assignment and toxicity category | Body mass index | Physical activity (MET hours per week) | |||||
|---|---|---|---|---|---|---|---|
| (n = 792) |
(n = 495) |
||||||
| Normal | Overweight | Obese | P | 0-9 | >9 | P a | |
| Paclitaxel, No. | 74 | 79 | 129 | 115 | 64 | ||
| Hematologic, No. (%) | 19 (25.7) | 19 (24.1) | 26 (20.2) | .63 | 27 (23.5) | 13 (20.3) | .63 |
| Nonhematologic, No. (%) | 45 (60.8) | 49 (62.0) | 79 (61.2) | .99 | 73 (63.5) | 40 (62.5) | .90 |
| Nab-paclitaxel, No. | 71 | 93 | 104 | 120 | 50 | ||
| Hematologic, No. (%) | 32 (45.1) | 52 (55.9) | 62 (59.6) | .16 | 69 (57.5) | 28 (56.0) | .86 |
| Nonhematologic, No. (%) | 49 (69.0) | 63 (67.7) | 76 (73.1) | .70 | 87 (72.5) | 34 (68.0) | .56 |
| Ixabepilone, No. | 64 | 76 | 102 | 106 | 40 | ||
| Hematologic, No. (%) | 8 (12.5) | 6 (7.9) | 14 (13.7) | .47 | 12 (11.3) | 5 (12.5) | .84 |
| Nonhematologic, No. (%) | 33 (51.6) | 51 (67.1) | 71 (69.6) | .05 | 65 (61.3) | 23 (57.5) | .67 |
a
Two-sided χ2 test. MET = metabolic equivalents of task.