Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between radiologic tissue composition metrics and risk of subsequent breast cancer development among women with BBD, overall and by BBD histological classificationa
| Radiologic tissue metricsb | Overall |
Nonproliferative |
Proliferative |
P het | |||
|---|---|---|---|---|---|---|---|
| Controls/Cases | OR (95% CI) | Controls/Cases | OR (95% CI) | Controls/Cases | OR (95% CI) | ||
| Absolute dense area (cm2) | |||||||
| Quartiles | |||||||
| Q1 (<21.87) | 76/59 | 1.00 (referent) | 54/36 | 1.00 (referent) | 22/23 | 1.00 (referent) | .84 |
| Q2 (21.87-35.54) | 75/79 | 1.21 (0.71 to 2.06) | 54/41 | 0.99 (0.52 to 1.91) | 21/38 | 2.05 (0.79 to 5.34) | |
| Q3 (35.54-58.94) | 75/89 | 1.28 (0.75 to 2.17) | 50/49 | 1.34 (0.69 to 2.59) | 25/40 | 1.16 (0.45 to 2.98) | |
| Q4 (>58.94) | 76/69 | 1.14 (0.66 to 1.95) | 59/42 | 1.09 (0.57 to 2.09) | 17/27 | 1.23 (0.41 to 3.67) | |
| Ptrend | .50 | .46 | .99 | ||||
| Per 10 cm2 increase | 302/296 | 1.02 (0.96 to 1.07) | 217/168 | 1.02 (0.95 to 1.09) | 85/128 | 1.00 (0.88 to 1.12) | |
| P | .58 | .61 | .95 | ||||
| Absolute nondense area (cm2) | |||||||
| Quartiles | |||||||
| Q1 (<59.98) | 75/86 | 1.00 (referent) | 56/48 | 1.00 (referent) | 19/38 | 1.00 (referent) | .22 |
| Q2 (59.98-101.24) | 76/79 | 0.88 (0.53 to 1.46) | 54/43 | 0.94 (0.51 to 1.73) | 22/36 | 0.76 (0.27 to 2.12) | |
| Q3 (101.24-164.69) | 75/99 | 0.97 (0.56 to 1.68) | 53/55 | 1.12 (0.56 to 2.22) | 22/44 | 0.67 (0.21 to 2.12) | |
| Q4 (>164.69) | 76/32 | 0.27 (0.13 to 0.54) | 54/22 | 0.40 (0.17 to 0.92) | 22/10 | 0.11 (0.02 to 0.54) | |
| Ptrend | .002 | .08 | .01 | ||||
| Per 10 cm2 increase | 302/296 | 0.95 (0.92 to 0.99) | 217/168 | 0.97 (0.94 to 1.01) | 85/128 | 0.88 (0.79 to 0.96) | |
| P | .005 | .17 | .006 | ||||
| Mammographic density (%) | |||||||
| Quartiles | |||||||
| Q1 (<14.67) | 75/49 | 1.00 (referent) | 53/31 | 1.00 (referent) | 22/18 | 1.00 (referent) | .75 |
| Q2 (14.67-28.39) | 76/78 | 1.58 (0.94 to 2.68) | 50/39 | 1.48 (0.77 to 2.86) | 26/39 | 1.69 (0.66 to 4.34) | |
| Q3 (28.39-43.76) | 76/82 | 1.88 (1.10 to 3.24) | 61/45 | 1.52 (0.79 to 2.93) | 15/37 | 3.26 (1.14 to 9.26) | |
| Q4 (>43.76) | 75/87 | 2.20 (1.20 to 4.03) | 53/53 | 2.29 (1.09 to 4.83) | 22/34 | 1.81 (0.56 to 5.93) | |
| Ptrend | .01 | .04 | .21 | ||||
| Per 10% increase | 302/296 | 1.12 (1.01 to 1.23) | 217/168 | 1.10 (0.96 to 1.23) | 85/128 | 1.15 (0.94 to 1.37) | |
| P | .03 | .15 | .16 | ||||
Benign breast disease (BBD) was classified as normal or nonproliferative and proliferative (with or without atypia). Phet = P value for heterogeneity of OR estimates by BBD histological classification.
Quartiles (Q1-Q4) of radiologic tissue composition metrics (absolute dense area [cm2], absolute nondense area [cm2], percent mammographic breast density [MBD] [%]) were defined based on their distributions among controls. Overall and in women with nonproliferative or proliferative disease (with or without atypia), unconditional logistic regression models were adjusted for age at menarche, parity and age at first live birth, body mass index, menopausal status and menopausal hormone therapy (MHT) use, bilateral oophorectomy, history of breast cancer in a first-degree relative, BBD histology, extent of lobular involution, calendar year of BBD diagnosis, and matching factors (age at BBD diagnosis and follow-up time from BBD to cancer), as well as histologic-ESP. Dense and nondense areas were mutually adjusted for one another.