Skip to main content
. Author manuscript; available in PMC: 2021 May 7.
Published in final edited form as: Alzheimers Dement. 2020 Aug 22;16(10):1372–1383. doi: 10.1002/alz.12104

FIGURE 1.

FIGURE 1

Negative association between tight junction proteins and soluble tau or apolipoprotein E (apoE). The claudin-5 (CLDN5)/CD31 (A) or occludin (OCLN)/CD31 (B) levels from temporal cortex of Alzheimer’s disease (AD) cases were plotted against soluble tau and soluble apoE levels. The correlation between tight junction proteins and tau or apoE (TBS fractions) was evaluated using Spearman’s correlation analysis. P-values <.0028 were considered statistically significant. An estimated regression line is shown on each figure to enhance visualization of negative correlations. C, Boxplots showing the levels of CLDN5/CD31 or OCLN/CD31 from AD cases according to soluble tau and apoE, both of which were dichotomized as low or high based on the sample median for ease of presentation. NS, not significant. Note the independent effects of soluble tau and apoE on tight junction protein levels